TC BioPharm plc changed its American Depositary Shares (ADS) ratio from 1 ADS for 20 ordinary shares to 1 ADS for 200 ordinary shares, effective August 5, 2024, impacting ADS holders by requiring them to exchange ten ADSs for one new ADS. Additionally, the exercise price of related warrants has increased from $500 to $5,000 as part of this adjustment.