On January 12, 2026, Karyopharm Therapeutics Inc. reported estimated total revenues of $33 million for Q4 2025 and $145 million for the full year 2025, with net product revenue from U.S. XPOVIO at approximately $32 million for Q4 2025 and $115 million for the full year. The company expects to maintain sufficient liquidity of approximately $64 million to support its operations into Q2 2026.