AstraZeneca PLC announced that their drug Enhertu has been approved in the U.S. for treating HER2-low or HER2-ultralow metastatic breast cancer as of January 28, 2025, following previous endocrine therapy. This approval, based on the DESTINY-Breast06 trial, demonstrates significant improvements in patient outcomes, with a reported median progression-free survival of 13.2 months for Enhertu compared to 8.1 months for chemotherapy.